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Paramagnetic Properties of Metal-Free Boron-Doped Graphene Quantum Dots and Their Application for Safe Magnetic Resonance Imaging.

ABSTRACT: A boron-doped graphene quantum dot (B-GQD) as a metal-free multimodal contrast agent (CA) for safe magnetic resonance imaging and fluorescence imaging is reported. In vivo T1 -weighted magnetic resonance images show that B-GQDs induce significant contrast enhancement on the heart, liver, spleen, and kidney, and sustain for more than 1 h, about 10 times longer than Gd-based CAs currently used in clinic.

SUBMITTER: Wang H

PROVIDER: S-EPMC5391173 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Paramagnetic Properties of Metal-Free Boron-Doped Graphene Quantum Dots and Their Application for Safe Magnetic Resonance Imaging.

Wang Hui H Revia Richard R Wang Kui K Kant Rajeev J RJ Mu Qingxin Q Gai Zheng Z Hong Kunlun K Zhang Miqin M

Advanced materials (Deerfield Beach, Fla.) 20161227 11

A boron-doped graphene quantum dot (B-GQD) as a metal-free multimodal contrast agent (CA) for safe magnetic resonance imaging and fluorescence imaging is reported. In vivo T<sub>1</sub> -weighted magnetic resonance images show that B-GQDs induce significant contrast enhancement on the heart, liver, spleen, and kidney, and sustain for more than 1 h, about 10 times longer than Gd-based CAs currently used in clinic. ...[more]

PMID: 28026064

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