Ontology highlight
ABSTRACT:
SUBMITTER: Botchkarev VV
PROVIDER: S-EPMC5391178 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Botchkarev Vladimir V VV Garabedian Mikael V MV Lemos Brenda B Paulissen Eric E Haber James E JE
Molecular biology of the cell 20170222 8
The budding yeast Polo-like kinase Cdc5 is a key regulator of many mitotic events. Cdc5 coordinates its functions spatially and temporally by changing its localization during the cell cycle: Cdc5 is imported into the nucleus in G2 phase and released to the cytoplasm in anaphase, where it accumulates at the bud neck. Cdc5 also localizes to the spindle pole bodies (SPBs) from S phase until the end of mitosis. Whether Cdc5 changes its SPB population during the cell cycle is not known. We find that ...[more]