Ontology highlight
ABSTRACT:
SUBMITTER: Iaea DB
PROVIDER: S-EPMC5391187 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Iaea David B DB Mao Shu S Lund Frederik W FW Maxfield Frederick R FR
Molecular biology of the cell 20170216 8
Cholesterol is an essential constituent of membranes in mammalian cells. The plasma membrane and the endocytic recycling compartment (ERC) are both highly enriched in cholesterol. The abundance and distribution of cholesterol among organelles are tightly controlled by a combination of mechanisms involving vesicular and nonvesicular sterol transport processes. Using the fluorescent cholesterol analogue dehydroergosterol, we examined sterol transport between the plasma membrane and the ERC using f ...[more]