Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5391209 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Zhang Xiaoyu X Spiegelman Nicole A NA Nelson Ornella D OD Jing Hui H Lin Hening H
eLife 20170413
The Ras family of GTPases are important in cell signaling and frequently mutated in human tumors. Understanding their regulation is thus important for studying biology and human diseases. Here, we report that a novel posttranslational mechanism, reversible lysine fatty acylation, regulates R-Ras2, a member of the Ras family. SIRT6, a sirtuin with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2. In mouse embryonic fibroblasts (MEFs), <i>Sirt6</i> knockout (KO ...[more]