Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells.

ABSTRACT:

Background

The aldo-keto reductase 1C3 (AKR1C3) has been heavily implicated in the propagation of prostate malignancy. AKR1C3 protein is elevated within prostate cancer tissue, it contributes to the formation of androgens and downstream stimulation of the androgen receptor (AR). Elevated expression of AKR1C3 is also reported in acute myeloid leukemia but the target nuclear receptors have been identified as members of the peroxisome-proliferator activated receptor (PPARs) subfamily. Thus, AKR1C3 cancer biology is likely to be tissue dependent and hormonally linked to the availability of ligands for both the steroidogenic and non-steroidogenic nuclear receptors.

Methods

In the current study we investigated the potential for AKR1C3 to regulate the availability of prostaglandin-

SUBMITTER: Doig CL 

PROVIDER: S-EPMC5391256 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature