Ontology highlight
ABSTRACT:
SUBMITTER: Wozniak MA
PROVIDER: S-EPMC539154 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Wozniak Michele A MA Kwong Lina L Chodniewicz David D Klemke Richard L RL Keely Patricia J PJ
Molecular biology of the cell 20041103 1
Although it is known that the spatial coordination of Rac and Rho activity is essential for cell migration, the molecular mechanisms regulating these GTPases during migration are unknown. We found that the expression of constitutively activated R-Ras (38V) blocked membrane protrusion and random migration. In contrast, expression of dominant negative R-Ras (41A) enhanced migrational persistence and membrane protrusion. Endogenous R-Ras is necessary for cell migration, as cells that were transfect ...[more]