Ontology highlight
ABSTRACT:
SUBMITTER: Gianfrancesco MA
PROVIDER: S-EPMC5391720 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Gianfrancesco Milena A MA Glymour M Maria MM Walter Stefan S Rhead Brooke B Shao Xiaorong X Shen Ling L Quach Hong H Hubbard Alan A Jónsdóttir Ingileif I Stefánsson Kári K Strid Pernilla P Hillert Jan J Hedström Anna A Olsson Tomas T Kockum Ingrid I Schaefer Catherine C Alfredsson Lars L Barcellos Lisa F LF
American journal of epidemiology 20170201 3
Multiple sclerosis (MS) is an autoimmune disease with both genetic and environmental risk factors. Recent studies indicate that childhood and adolescent obesity double the risk of MS, but this association may reflect unmeasured confounders rather than causal effects of obesity. We used separate-sample Mendelian randomization to estimate the causal effect of body mass index (BMI) on susceptibility to MS. Using data from non-Hispanic white members of the Kaiser Permanente Medical Care Plan of Nort ...[more]