Ontology highlight
ABSTRACT:
SUBMITTER: Mitchell SE
PROVIDER: S-EPMC5392262 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Mitchell Sharon E SE Tang ZhanHui Z Kerbois Celine C Delville Camille C Derous Davina D Green Cara L CL Wang Yingchun Y Han Jackie J D JJ Chen Luonan L Douglas Alex A Lusseau David D Promislow Daniel E L DE Speakman John R JR
Oncotarget 20170301 11
Under calorie restriction (CR) animals need to lower energy demands. Whether this involves a reduction in cellular metabolism is an issue of contention. We exposed C57BL/6 mice to graded CR for 3 months, measured BMR and dissected out 20 body compartments. From a separate age-matched group (n=57), we built 7 predictive models for BMR. Unadjusted BMR declined with severity of restriction. Comparison of measured and predicted BMR from the simple models suggested suppression occurred. The extent of ...[more]