Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5392370 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Wang Yuli Y Zhang Pengju P Wang Yunshan Y Zhan Panpan P Liu Chunyan C Mao Jian-Hua JH Wei Guangwei G
Cancer research 20170216 8
The ErbB3 receptor-binding protein EBP1 encodes two alternatively spliced isoforms P48 and P42. While there is evidence of differential roles for these isoforms in tumorigenesis, little is known about their underlying mechanisms. Here, we demonstrate that EBP1 isoforms interact with the SCF-type ubiquitin ligase FBXW7 in distinct ways to exert opposing roles in tumorigenesis. EBP1 P48 bound to the WD domain of FBXW7 as an oncogenic substrate of FBXW7. EBP1 P48 binding sequestered FBXW7α to the c ...[more]