Ontology highlight
ABSTRACT:
SUBMITTER: Moraru A
PROVIDER: S-EPMC5392496 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Moraru Alexandra A Cakan-Akdogan Gulcin G Strassburger Katrin K Males Matilda M Mueller Sandra S Jabs Markus M Muelleder Michael M Frejno Martin M Braeckman Bart P BP Ralser Markus M Teleman Aurelio A AA
Developmental cell 20170401 1
Human susceptibility to obesity is mainly genetic, yet the underlying evolutionary drivers causing variation from person to person are not clear. One theory rationalizes that populations that have adapted to warmer climates have reduced their metabolic rates, thereby increasing their propensity to store energy. We uncover here the function of a gene that supports this theory. THADA is one of the genes most strongly selected during evolution as humans settled in different climates. We report here ...[more]