Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC5392561 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Liu Yanli Y Qin Su S Lei Ming M Tempel Wolfram W Zhang Yuzhe Y Loppnau Peter P Li Yanjun Y Min Jinrong J
The Journal of biological chemistry 20170221 14
Heterochromatin protein 1 (HP1), a highly conserved non-histone chromosomal protein in eukaryotes, plays important roles in the regulation of gene transcription. Each of the three human homologs of HP1 includes a chromoshadow domain (CSD). The CSD interacts with various proteins bearing the P<i>X</i>V<i>X</i>L motif but also with a region of histone H3 that bears the similar P<i>XX</i>V<i>X</i>L motif. The latter interaction has not yet been resolved in atomic detail. Here we demonstrate that th ...[more]