Ontology highlight
ABSTRACT:
SUBMITTER: Stefanucci A
PROVIDER: S-EPMC5392763 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20170314 4
d-Pen<sup>2</sup>,d-Pen<sup>5</sup> enkephalin (DPDPE) is one of the most selective synthetic peptide agonists targeting the δ-opioid receptor. Three cyclic analogues of DPDPE containing a xylene bridge in place of disulfide bond have been synthesized and fully characterized as opioid receptors agonists. The <i>in vitro</i> activity was investigated showing a good affinity of <b>7a</b>-<b>c</b> for μ- and δ-receptors. <i>In vivo</i> biological assays revealed that <b>7b</b> is the most potent an ...[more]