Ontology highlight
ABSTRACT:
SUBMITTER: Erceg J
PROVIDER: S-EPMC5393054 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Erceg Jelena J Pakozdi Tibor T Marco-Ferreres Raquel R Ghavi-Helm Yad Y Girardot Charles C Bracken Adrian P AP Furlong Eileen E M EE
Genes & development 20170301 6
Developmental gene expression is tightly regulated through enhancer elements, which initiate dynamic spatio-temporal expression, and Polycomb response elements (PREs), which maintain stable gene silencing. These two <i>cis</i>-regulatory functions are thought to operate through distinct dedicated elements. By examining the occupancy of the <i>Drosophila</i> pleiohomeotic repressive complex (PhoRC) during embryogenesis, we revealed extensive co-occupancy at developmental enhancers. Using an estab ...[more]