Ontology highlight
ABSTRACT:
SUBMITTER: Levikova M
PROVIDER: S-EPMC5393063 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Levikova Maryna M Pinto Cosimo C Cejka Petr P
Genes & development 20170323 5
DNA2 nuclease-helicase functions in DNA replication and recombination. This requires the nuclease of DNA2, while, in contrast, the role of the helicase activity has been unclear. We now show that the motor activity of both recombinant yeast and human DNA2 promotes efficient degradation of long stretches of ssDNA, particularly in the presence of the replication protein A. This degradation is further stimulated by a direct interaction with a cognate RecQ family helicase, which functions with DNA2 ...[more]