MiR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis.
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ABSTRACT:
SUBMITTER: Rosenberger CM
PROVIDER: S-EPMC5393898 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis.
Rosenberger Carrie M CM Podyminogin Rebecca L RL Diercks Alan H AH Treuting Piper M PM Peschon Jacques J JJ Rodriguez David D Gundapuneni Madhumati M Weiss Mitchell J MJ Aderem Alan A
PLoS pathogens 20170405 4
Antiviral responses must rapidly defend against infection while minimizing inflammatory damage, but the mechanisms that regulate the magnitude of response within an infected cell are not well understood. miRNAs are small non-coding RNAs that suppress protein levels by binding target sequences on their cognate mRNA. Here, we identify miR-144 as a negative regulator of the host antiviral response. Ectopic expression of miR-144 resulted in increased replication of three RNA viruses in primary mouse ...[more]
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