Ontology highlight
ABSTRACT:
SUBMITTER: Mostaghel EA
PROVIDER: S-EPMC5393923 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Mostaghel Elahe A EA Martin Paul S PS Mongovin Stephen S Frayo Shani S Zhang Ailin A Edlefsen Kerstin L KL Press Oliver W OW Gopal Ajay K AK
Experimental hematology 20170121
Mantle cell lymphoma (MCL) affects approximately 4500 patients/year in the US and demonstrates a male to female ratio of approximately 4:1. While the pathobiology underlying this ratio is unknown, the hematopoietic system is characterized by sex-related differences in androgen receptor (AR) expression, leading us to hypothesize that the male-biased incidence of MCL may reflect sex-related differences in AR signaling during MCL lymphomagenesis. To explore the AR axis in MCL, we evaluated AR expre ...[more]