Methodology for a trial of brain-centered versus anticholinergic therapy in women with urgency urinary incontinence.

ABSTRACT:

Introduction and hypothesis

We describe the rationale and methodology for a study comparing mind-body treatment and pharmacotherapy in women with urgency urinary incontinence (UUI). To explore brain associations in UUI, a subset of patients will also undergo functional magnetic resonance imaging (fMRI). We hypothesize that hypnotherapy, a mind-body intervention, will be at least as effective as pharmacotherapy in treating UUI. We also hypothesize that fMRI findings will change following treatment, with changes potentially differing between groups.

Methods

We describe the development and design challenges of a study comparing the efficacy of hypnotherapy and conventional pharmacotherapy in the treatment of UUI. The study randomizes women to either of these treatments, and out

SUBMITTER: Komesu YM 

PROVIDER: S-EPMC5393944 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature