Ontology highlight
ABSTRACT:
SUBMITTER: Zhong Z
PROVIDER: S-EPMC5394268 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Nature communications 20170411
Inducing tumour-specific adaptive immunity, such as cytotoxic T lymphocyte (CTL) response, can result in promising antitumour effect against several human malignancies, especially in combination with immune checkpoint blockade strategies. However, little is known whether activation of innate immunity can lead to direct tumoricidal effect. Here, we develop a papilloma pseudovirus-based oral immunotherapeutic approach that shows strong tumoricidal effects in the gut, resulting in an almost tripled ...[more]