Dataset Information

The Association of Serum Thrombomodulin with Endothelial Injuring Factors in Abdominal Aortic Aneurysm.

ABSTRACT: Background. The aim of the present study was to evaluate the concentration of serum thrombomodulin (sTM) in the AAA patients and to examine its correlation with various factors which may potentially participate in the endothelial injury. Materials and Methods. Forty-one patients with AAA were involved and divided into subgroups based on different criteria. Concentration of sTM was measured using enzyme-linked-immunosorbent assay (ELISA). The results were compared with those obtained in 30 healthy age- and sex-matched volunteers. Results. The higher concentration of sTM was observed in AAA patients compared with those in controls volunteers [2.37 (1.97-2.82)?ng/mL versus 3.93 (2.43-9.20)?ng/mL, P < 0.001]. An elevated sTM associated significantly with increased triglycerides (TAG) [P = 0.022], cholesterol [P = 0.029], hsCRP [P = 0.031], and advanced glycation end products (AGEs) [P = 0.033]. Conclusions. The elevation of serum sTM level suggests that endothelial damage occurs in AAA pathogenesis. The correlations observed indicate that lipids abnormalities, inflammation, and oxidative stress may be involved in this destructive process.

SUBMITTER: Budzyn M

PROVIDER: S-EPMC5394357 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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The Association of Serum Thrombomodulin with Endothelial Injuring Factors in Abdominal Aortic Aneurysm.

Budzyń Magdalena M Gryszczyńska Bogna B Majewski Wacław W Krasiński Zbigniew Z Kasprzak Magdalena Paulina MP Formanowicz Dorota D Strzyżewski Krzysztof Wojciech KW Iskra Maria M

BioMed research international 20170403

<i>Background.</i> The aim of the present study was to evaluate the concentration of serum thrombomodulin (sTM) in the AAA patients and to examine its correlation with various factors which may potentially participate in the endothelial injury. <i>Materials and Methods.</i> Forty-one patients with AAA were involved and divided into subgroups based on different criteria. Concentration of sTM was measured using enzyme-linked-immunosorbent assay (ELISA). The results were compared with those obtaine ...[more]

PMID: 28473982

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Project description:Background: Abdominal Aortic Aneurysm (AAA) rupture is the thirteenth leading cause of death in the U.S. and a major cause of death in the elderly. Since most AAAs are asymptomatic, mortality could be greatly reduced by determining which patients are at risk, then screening those patients prior to a rupture. Our aim was to determine which clinical and genetic risk factors are associated with AAA. Methods: This was a case- control study of patients from the Geisinger Vascular Clinic and the Geisinger MyCode Project (a biobanking project of Geisinger Clinic patients who volunteered to participate in genetic research projects). Clinical and environmental risk factor data was obtained from patient electronic medical records (EMR) and analyzed by multivariate logistic regression. In a subset of participants, we also analyzed three promising genetic polymorphisms, two from a prior genome-wide association study in this population (rs12039875, 1q41; rs7635818, 3p12.3) and one from the recent literature (rs10757278, 9p21). The genetic data was combined with the clinical data using multivariate logistic regression. Results: In the clinical analysis the number of Vascular Clinic and MyCode AAA cases totaled 722, with 11,761 controls. Adjusted OR showed a significant AAA risk for age, gender, smoking, intermittent claudication and peripheral artery disease, while body mass index (BMI) and diabetes were surprisingly protective. The genetic analysis consisted of 502 AAA cases and 295 controls from the Vascular Clinic. The GC genotype of rs7635818 showed an increased risk, but the rs12039875 AA genotype showed a significant protective effect when controlling for the clinical variables. This SNP is located in KCNK2, a gene in the potassium channel protein family. Although this gene has not previously been linked with AAA, our laboratory showed that this gene is expressed in vascular tissue. Conclusions: Our study indicates a significant elevated risk of AAA for individuals who are older, male, ever smoked, have peripheral artery disease and a GC genotype of rs7635818. Higher BMI, diabetes and the AA genotype of rs12039875 in the KCNK2 gene significantly lower AAA risk. This is one of the first studies to utilize the MyCode population in a research study and establish this population source as a valuable and convenient asset of Geisinger Health System for clinical research.

Dataset Information

The Association of Serum Thrombomodulin with Endothelial Injuring Factors in Abdominal Aortic Aneurysm.

Publications

The Association of Serum Thrombomodulin with Endothelial Injuring Factors in Abdominal Aortic Aneurysm.

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