Ontology highlight
ABSTRACT:
SUBMITTER: Salman AM
PROVIDER: S-EPMC5394459 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Salman Ahmed M AM Montoya-Díaz Eduardo E West Heather H Lall Amar A Atcheson Erwan E Lopez-Camacho Cesar C Ramesar Jai J Bauza Karolis K Collins Katharine A KA Brod Florian F Reis Fernando F Pappas Leontios L González-Cerón Lilia L Janse Chris J CJ Hill Adrian V S AVS Khan Shahid M SM Reyes-Sandoval Arturo A
Scientific reports 20170418
Development of a protective and broadly-acting vaccine against the most widely distributed human malaria parasite, Plasmodium vivax, will be a major step towards malaria elimination. However, a P. vivax vaccine has remained elusive by the scarcity of pre-clinical models to test protective efficacy and support further clinical trials. In this study, we report the development of a highly protective CSP-based P. vivax vaccine, a virus-like particle (VLP) known as Rv21, able to provide 100% sterile ...[more]