Ontology highlight
ABSTRACT:
SUBMITTER: Koda N
PROVIDER: S-EPMC5394762 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Koda Naoki N Sato Tempei T Shinohara Masahiro M Ichinose Shizuko S Ito Yoshiaki Y Nakamichi Ryo R Kayama Tomohiro T Kataoka Kensuke K Suzuki Hidetsugu H Moriyama Keiji K Asahara Hiroshi H
Development (Cambridge, England) 20161219 2
The periodontal ligament (PDL), which connects the teeth to the alveolar bone, is essential for periodontal tissue homeostasis. Although the significance of the PDL is recognized, molecular mechanisms underlying PDL function are not well known. We report that mohawk homeobox (Mkx), a tendon-specific transcription factor, regulates PDL homeostasis by preventing its degeneration. Mkx is expressed in the mouse PDL at the age of 10 weeks and expression remained at similar levels at 12 months. In Mkx ...[more]