Critical assessment of methods of protein structure prediction: Progress and new directions in round XI.

ABSTRACT: Modeling of protein structure from amino acid sequence now plays a major role in structural biology. Here we report new developments and progress from the CASP11 community experiment, assessing the state of the art in structure modeling. Notable points include the following: (1) New methods for predicting three dimensional contacts resulted in a few spectacular template free models in this CASP, whereas models based on sequence homology to proteins with experimental structure continue to be the most accurate. (2) Refinement of initial protein models, primarily using molecular dynamics related approaches, has now advanced to the point where the best methods can consistently (though slightly) improve nearly all models. (3) The use of relatively sparse NMR constraints dramatically improves th

SUBMITTER: Moult J 

PROVIDER: S-EPMC5394799 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature