Ontology highlight
ABSTRACT:
SUBMITTER: Zheng J
PROVIDER: S-EPMC5395024 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Zheng Jun J Rubin Eric J EJ Bifani Pablo P Mathys Vanessa V Lim Vivian V Au Melvin M Jang Jichan J Nam Jiyoun J Dick Thomas T Walker John R JR Pethe Kevin K Camacho Luis R LR
The Journal of biological chemistry 20130618 32
para-Aminosalicylic acid (PAS) is one of the antimycobacterial drugs currently used for multidrug-resistant tuberculosis. Although it has been in clinical use for over 60 years, its mechanism(s) of action remains elusive. Here we report that PAS is a prodrug targeting dihydrofolate reductase (DHFR) through an unusual and novel mechanism of action. We provide evidences that PAS is incorporated into the folate pathway by dihydropteroate synthase (DHPS) and dihydrofolate synthase (DHFS) to generate ...[more]