Erythrocyte survival is controlled by microRNA-142.
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ABSTRACT:
SUBMITTER: Rivkin N
PROVIDER: S-EPMC5395108 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Erythrocyte survival is controlled by microRNA-142.
Rivkin Natalia N Chapnik Elik E Mildner Alexander A Barshtein Gregory G Porat Ziv Z Kartvelishvily Elena E Dadosh Tali T Birger Yehudit Y Amir Gail G Yedgar Saul S Izraeli Shai S Jung Steffen S Hornstein Eran E
Haematologica 20161201 4
Hematopoietic-specific microRNA-142 is a critical regulator of various blood cell lineages, but its role in erythrocytes is unexplored. Herein, we characterize the impact of microRNA-142 on erythrocyte physiology and molecular cell biology, using a mouse loss-of-function allele. We report that microRNA-142 is required for maintaining the typical erythrocyte biconcave shape and structural resilience, for the normal metabolism of reactive oxygen species, and for overall lifespan. microRNA-142 furt ...[more]
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