Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC5395199 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Zhao Yu Y Wang Liguo L Ren Shancheng S Wang Lan L Blackburn Patrick R PR McNulty Melissa S MS Gao Xu X Qiao Meng M Vessella Robert L RL Kohli Manish M Zhang Jun J Karnes R Jeffrey RJ Tindall Donald J DJ Kim Youngsoo Y MacLeod Robert R Ekker Stephen C SC Kang Tiebang T Sun Yinghao Y Huang Haojie H
Cell reports 20160407 3
The androgen receptor (AR) is required for castration-resistant prostate cancer (CRPC) progression, but the function and disease relevance of AR-bound enhancers remain unclear. Here, we identify a group of AR-regulated enhancer RNAs (e.g., PSA eRNA) that are upregulated in CRPC cells, patient-derived xenografts (PDXs), and patient tissues. PSA eRNA binds to CYCLIN T1, activates P-TEFb, and promotes cis and trans target gene transcription by increasing serine-2 phosphorylation of RNA polymerase I ...[more]