Augmented Th17-type immune responses in preterm neonates exposed to histologic chorioamnionitis.

ABSTRACT:

Background

Histologic chorioamnionitis (HCA) is a placental inflammatory disorder that frequently precedes preterm delivery. HCA increases risk for long-standing inflammatory injury and may influence immune programming, particularly in preterm (PT) neonates. We hypothesized that HCA exposure is associated with an increased circulating frequency of proinflammatory, Th17-type responses.

Methods

Placental cord blood was collected from HCA-exposed or control neonates (23-41 wk gestation). Frequencies of Th17 and T regulatory (Treg) cells and assessments of Th17-type features in CD4 and Treg cells were determined by flow cytometric analysis.

Results

Cord blood samples from 31 PT and 17 term neonates were analyzed by flow cytometry. A diagnosis of HCA in extremely PT (EPT,

SUBMITTER: Rito DC 

PROVIDER: S-EPMC5395318 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature