Ontology highlight
ABSTRACT:
SUBMITTER: Deng X
PROVIDER: S-EPMC5395579 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Deng Xuan X Li Mei M Pan Xiaolei X Zheng Ruiping R Liu Chang C Chen Fei F Liu Xue X Cheng Zhihui Z Jin Shouguang S Wu Weihui W
Frontiers in microbiology 20170419
Fis is a versatile DNA binding protein in bacteria. It has been demonstrated in multiple bacteria that Fis plays crucial roles in regulating bacterial virulence factors and optimizing bacterial adaptation to various environments. However, the role of Fis in <i>Pseudomonas aeruginosa</i> virulence as well as gene regulation remains largely unknown. Here, we found that Fis was required for the virulence of <i>P. aeruginosa</i> in a murine acute pneumonia model. Transcriptome analysis revealed that ...[more]