Disrupted Topology of Frontostriatal Circuits Is Linked to the Severity of Insomnia.

ABSTRACT: Insomnia is one of the most common health complaints, with a high prevalence of 30~50% in the general population. In particular, neuroimaging research has revealed that widespread dysfunctions in brain regions involved in hyperarousal are strongly correlated with insomnia. However, whether the topology of the intrinsic connectivity is aberrant in insomnia remains largely unknown. In this study, resting-state functional magnetic resonance imaging (rsfMRI) in conjunction with graph theoretical analysis, was used to construct functional connectivity matrices and to extract the attribute features of the small-world networks in insomnia. We examined the alterations in global and local small-world network properties of the distributed brain regions that are predominantly implicated in the fronto

SUBMITTER: Lu FM 

PROVIDER: S-EPMC5395640 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature