Ontology highlight
ABSTRACT:
SUBMITTER: Anthony D
PROVIDER: S-EPMC5395724 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Anthony Desiree D McQualter Jonathan L JL Bishara Maria M Lim Ee X EX Yatmaz Selcuk S Seow Huei Jiunn HJ Hansen Michelle M Thompson Michelle M Hamilton John A JA Irving Louis B LB Levy Bruce D BD Vlahos Ross R Anderson Gary P GP Bozinovski Steven S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20140520 9
Serum amyloid A (SAA) is expressed locally in chronic inflammatory conditions such as chronic obstructive pulmonary disease (COPD), where macrophages that do not accord with the classic M1/M2 paradigm also accumulate. In this study, the role of SAA in regulating macrophage differentiation was investigated in vitro using human blood monocytes from healthy subjects and patients with COPD and in vivo using an airway SAA challenge model in BALB/c mice. Differentiation of human monocytes with SAA sti ...[more]