Metabolic profiles in heart failure due to non-ischemic cardiomyopathy at rest and under exercise.

ABSTRACT:

Aims

Identification of metabolic signatures in heart failure (HF) patients and evaluation of their diagnostic potential to discriminate HF patients from healthy controls during baseline and exercise conditions.

Methods

Plasma samples were collected from 22 male HF patients with non-ischemic idiopathic cardiomyopathy and left ventricular systolic dysfunction and 19 healthy controls before (t0), at peak (t1) and 1 h after (t2) symptom-limited cardiopulmonary exercise testing. Two hundred fifty-two metabolites were quantified by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography (LC)-MS/MS-based metabolite profiling.

Results

Plasma metabolite profiles clearly differed between HF patients and controls at t0 (P < 0.05). The metabolic signature of

SUBMITTER: Mueller-Hennessen M 

PROVIDER: S-EPMC5396036 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature