Clinical-pharmacogenetic models for personalized cancer treatment: application to malignant mesothelioma.
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ABSTRACT:
SUBMITTER: Goricar K
PROVIDER: S-EPMC5396189 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Clinical-pharmacogenetic models for personalized cancer treatment: application to malignant mesothelioma.
Goričar Katja K Kovač Viljem V Dolžan Vita V
Scientific reports 20170419
Large interindividual differences in treatment outcome are observed in cancer patients undergoing chemotherapy. Our aim was to develop and validate clinical-pharmacogenetic prediction models of gemcitabine/cisplatin or pemetrexed/cisplatin treatment outcome and develop an algorithm for genotype-based treatment recommendations in malignant mesothelioma (MM). We genotyped 189 MM patients for polymorphisms in gemcitabine, pemetrexed and cisplatin metabolism, transport and drug target genes and DNA ...[more]
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