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RAD-ADAPT: Software for modelling clonogenic assay data in radiation biology.


ABSTRACT: We present a comprehensive software program, RAD-ADAPT, for the quantitative analysis of clonogenic assays in radiation biology. Two commonly used models for clonogenic assay analysis, the linear-quadratic model and single-hit multi-target model, are included in the software. RAD-ADAPT uses maximum likelihood estimation method to obtain parameter estimates with the assumption that cell colony count data follow a Poisson distribution. The program has an intuitive interface, generates model prediction plots, tabulates model parameter estimates, and allows automatic statistical comparison of parameters between different groups. The RAD-ADAPT interface is written using the statistical software R and the underlying computations are accomplished by the ADAPT software system for pharmacokinetic/pharmacodynamic systems analysis. The use of RAD-ADAPT is demonstrated using an example that examines the impact of pharmacologic ATM and ATR kinase inhibition on human lung cancer cell line A549 after ionizing radiation.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5396547 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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RAD-ADAPT: Software for modelling clonogenic assay data in radiation biology.

Zhang Yaping Y   Hu Kaiqiang K   Beumer Jan H JH   Bakkenist Christopher J CJ   D'Argenio David Z DZ  

DNA repair 20170220


We present a comprehensive software program, RAD-ADAPT, for the quantitative analysis of clonogenic assays in radiation biology. Two commonly used models for clonogenic assay analysis, the linear-quadratic model and single-hit multi-target model, are included in the software. RAD-ADAPT uses maximum likelihood estimation method to obtain parameter estimates with the assumption that cell colony count data follow a Poisson distribution. The program has an intuitive interface, generates model predic  ...[more]

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