Dataset Information

Sleep duration and quality in relation to chronic kidney disease and glomerular hyperfiltration in healthy men and women.

ABSTRACT:

Background

It is unclear whether sleep duration and quality are associated with chronic kidney disease (CKD) and glomerular hyperfiltration. The aim of this study was to examine the association of sleep duration and quality with CKD and glomerular hyperfiltration in young and middle-aged adults.

Methods

We conducted a cross-sectional study of men and women who underwent a health checkup examination, including assessment of sleep duration and quality (n = 241,607). Chronic kidney disease (CKD) was defined as an estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73 m2, and glomerular hyperfiltration was defined as eGFR above the age-/sex-specific 95th percentile.

Results

In a multinomial logistic regression analysis adjusting for relevant confounders, the adjusted prevalence ratios for CKD (95% confidence interval) comparing sleep durations of ≤ 5, 6, 8, and 9 hours with 7 hours were 1.22 (0.95-1.55), 0.93 (0.75-1.14), 0.97 (0.75-1.26), and 1.56 (1.06-2.30) in men and 0.98 (0.68-1.43), 1.03 (0.72-1.46), 1.39 (0.97-2.00), and 1.31 (0.78-2.22) in women, respectively. The corresponding prevalence ratios (95% confidence interval) for glomerular hyperfiltration were 1.00 (0.93-1.08), 0.97 (0.91-1.03), 1.03 (0.94-1.13), and 1.39 (1.13-1.72) in men and 1.04 (0.95-1.14), 0.96 (0.90-1.04), 1.11 (1.02-1.20), and 1.28 (1.14-1.45) in women, respectively. Poor subjective sleep quality was associated with glomerular hyperfiltration in men and women.

Conclusion

In this large study of young and middle-aged adults, we found that long sleep duration was associated with CKD and glomerular hyperfiltration. Additionally, poor subjective sleep quality was associated with increased prevalence of glomerular hyperfiltration, suggesting the importance of adequate quantity and quality of sleep for kidney function.

SUBMITTER: Kim CW

PROVIDER: S-EPMC5396878 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Sleep duration and quality in relation to chronic kidney disease and glomerular hyperfiltration in healthy men and women.

Kim Chan-Won CW Chang Yoosoo Y Sung Eunju E Yun Kyung Eun KE Jung Hyun-Suk HS Ko Byung-Joon BJ Kwon Min-Jung MJ Hyun Young Youl YY Lee Kyu-Beck KB Kim Hyang H Shin Hocheol H Ryu Seungho S

PloS one 20170419 4

<h4>Background</h4>It is unclear whether sleep duration and quality are associated with chronic kidney disease (CKD) and glomerular hyperfiltration. The aim of this study was to examine the association of sleep duration and quality with CKD and glomerular hyperfiltration in young and middle-aged adults.<h4>Methods</h4>We conducted a cross-sectional study of men and women who underwent a health checkup examination, including assessment of sleep duration and quality (n = 241,607). Chronic kidney d ...[more]

PMID: 28423054

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Dataset Information

Sleep duration and quality in relation to chronic kidney disease and glomerular hyperfiltration in healthy men and women.

Background

Methods

Results

Conclusion

Publications

Sleep duration and quality in relation to chronic kidney disease and glomerular hyperfiltration in healthy men and women.

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