Ontology highlight
ABSTRACT:
SUBMITTER: Pena-Diaz P
PROVIDER: S-EPMC5397073 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Peña-Diaz Priscila P Vancová Marie M Resl Christian C Field Mark C MC Lukeš Julius J
PLoS pathogens 20170407 4
The kinetoplast (k), the uniquely packaged mitochondrial DNA of trypanosomatid protists is formed by a catenated network of minicircles and maxicircles that divide and segregate once each cell cycle. Although many proteins involved in kDNA replication and segregation are now known, several key steps in the replication mechanism remain uncharacterized at the molecular level, one of which is the nabelschnur or umbilicus, a prominent structure which in the mammalian parasite Trypanosoma brucei conn ...[more]