Ontology highlight
ABSTRACT:
SUBMITTER: Federico L
PROVIDER: S-EPMC5397135 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Federico Lorenzo L Chong Zechen Z Zhang Dong D McGrail Daniel J DJ Zhao Wei W Jeong Kang Jin KJ Vellano Christopher P CP Ju Zhenlin Z Gagea Mihai M Liu Shuying S Mitra Shreya S Dennison Jennifer B JB Lorenzi Philip L PL Cardnell Robert R Diao Lixia L Wang Jing J Lu Yiling Y Byers Lauren A LA Perou Charles M CM Lin Shiaw-Yih SY Mills Gordon B GB
Science advances 20170419 4
We previously demonstrated that altered activity of lysophosphatidic acid in murine mammary glands promotes tumorigenesis. We have now established and characterized a heterogeneous collection of mouse-derived syngeneic transplants (MDSTs) as preclinical platforms for the assessment of personalized pharmacological therapies. Detailed molecular and phenotypic analyses revealed that MDSTs are the most heterogeneous group of genetically engineered mouse models (GEMMs) of breast cancer yet observed. ...[more]