Ontology highlight
ABSTRACT:
SUBMITTER: Howard MJ
PROVIDER: S-EPMC5397181 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Howard Michael J MJ Rodriguez Yesenia Y Wilson Samuel H SH
Nucleic acids research 20170401 7
DNA polymerase (Pol) β maintains genome fidelity by catalyzing DNA synthesis and removal of a reactive DNA repair intermediate during base excision repair (BER). Situated within the middle of the BER pathway, Pol β must efficiently locate its substrates before damage is exacerbated. The mechanisms of damage search and location by Pol β are largely unknown, but are critical for understanding the fundamental features of the BER pathway. We developed a processive search assay to determine if Pol β ...[more]