Ontology highlight
ABSTRACT:
SUBMITTER: Greene JM
PROVIDER: S-EPMC5397382 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Greene J M JM Dash P P Roy S S McMurtrey C C Awad W W Reed J S JS Hammond K B KB Abdulhaqq S S Wu H L HL Burwitz B J BJ Roth B F BF Morrow D W DW Ford J C JC Xu G G Bae J Y JY Crank H H Legasse A W AW Dang T H TH Greenaway H Y HY Kurniawan M M Gold M C MC Harriff M J MJ Lewinsohn D A DA Park B S BS Axthelm M K MK Stanton J J JJ Hansen S G SG Picker L J LJ Venturi V V Hildebrand W W Thomas P G PG Lewinsohn D M DM Adams E J EJ Sacha J B JB
Mucosal immunology 20161019 3
Studies on mucosal-associated invariant T cells (MAITs) in nonhuman primates (NHP), a physiologically relevant model of human immunity, are handicapped due to a lack of macaque MAIT-specific reagents. Here we show that while MR1 ligand-contact residues are conserved between human and multiple NHP species, three T-cell receptor contact-residue mutations in NHP MR1 diminish binding of human MR1 tetramers to macaque MAITs. Construction of naturally loaded macaque MR1 tetramers facilitated identific ...[more]