Immunity as a predictor of anti-malarial treatment failure: a systematic review.

ABSTRACT:

Background

Naturally acquired immunity can reduce parasitaemia and potentially influence anti-malarial treatment outcomes; however, evidence for this in the current literature provides conflicted results. The available evidence was synthesized to determine and quantify the association between host immunity and anti-malarial treatment failure.

Methods

Four databases were searched to identify studies investigating malaria antibody levels in patients receiving anti-malarial treatment for symptomatic malaria with treatment failure recorded according to the World Health Organization classification. Odds ratios or hazard ratios were extracted or calculated to quantify the association between malarial antibody levels and treatment failure, and findings from different studies were v

SUBMITTER: O'Flaherty K 

PROVIDER: S-EPMC5397737 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature