Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC539810 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Wang Yuhong Y Baskin J Spencer JS Xia Tianbing T Zewail Ahmed H AH
Proceedings of the National Academy of Sciences of the United States of America 20041215 52
Femtosecond to nanosecond dynamics of O(2) rebinding to human WT myoglobin and its mutants, V68F and I107F, have been studied by using transient absorption. The results are compared with NO rebinding. Even though the immediate environment around the heme binding site is changed by the mutations, the picosecond geminate rebinding of oxygen is at most minimally affected. On the other hand, the V68F (E11) mutation causes drastic differences in rebinding on the nanosecond time scale, whereas the eff ...[more]