Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez SP
PROVIDER: S-EPMC5399229 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Fernandez Sebastian P SP Muzerelle Aude A Scotto-Lomassese Sophie S Barik Jacques J Gruart Agnès A Delgado-García José M JM Gaspar Patricia P
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20160727 2
Serotonin (5-HT) deficiency occurs in a number of brain disorders that affect cognitive function. However, a direct causal relationship between 5-HT hypo-transmission and memory and underlying mechanisms has not been established. We used mice with a constitutive depletion of 5-HT brain levels (Pet1KO mice) to analyze the contribution of 5-HT to different forms of learning and memory. Pet1KO mice exhibited a striking deficit in novel object recognition memory, a hippocampal-dependent task. No alt ...[more]