Vitamin D receptor, Retinoid X receptor and peroxisome proliferator-activated receptor ? are overexpressed in BRCA1 mutated breast cancer and predict prognosis.

ABSTRACT: BRCA1 mutated breast cancers are commonly diagnosed as negative for classical hormone receptors i.e. estrogen receptor, progesterone receptor and/or Her2. Due to these common targets being absent the application of anti-endocrine therapies is rather limited and a certain focus has been set on discovering alternative target molecules. We recently highlighted thyroid hormone receptors (TRs) to predict prognosis in breast cancer patients that had been diagnosed a BRCA1 germline mutation. Vitamin D Receptor (VDR), Retinoid X Receptor (RXR) and Peroxisome Proliferator-activated Receptor ? (PPAR?) are known to interact with TRs by forming functional heterodimers. Whether VDR, RXR or PPAR? are expressed in BRCA1 mutated breast cancer or may even be present in case of triple negativity is not known. Hence the current study aimed to investigate VDR, RXR and PPAR? in BRCA1 mut breast cancer and to test whether any of the three may be associated with clinico-pathological criteria including overall survival.This study analyzed VDR, RXR and PPAR? by immunohistochemistry in BRCA1 associated (n?=?38) and sporadic breast cancer (n?=?79). Receptors were quantified by applying an established scoring system (IR-score) and were tested for association with clinico-pathological variables.VDR, RXR and PPAR? were detected in over 90% of triple negative BRCA1 mut breast cancer and were significantly (VDR: p?

SUBMITTER: Heublein S 

PROVIDER: S-EPMC5399435 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature