Ontology highlight
ABSTRACT:
SUBMITTER: Matsuoka TA
PROVIDER: S-EPMC5399608 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Matsuoka Taka-Aki TA Kawashima Satoshi S Miyatsuka Takeshi T Sasaki Shugo S Shimo Naoki N Katakami Naoto N Kawamori Dan D Takebe Satomi S Herrera Pedro L PL Kaneto Hideaki H Stein Roland R Shimomura Iichiro I
Diabetes 20170221 5
Among the therapeutic avenues being explored for replacement of the functional islet β-cell mass lost in type 1 diabetes (T1D), reprogramming of adult cell types into new β-cells has been actively pursued. Notably, mouse islet α-cells will transdifferentiate into β-cells under conditions of near β-cell loss, a condition similar to T1D. Moreover, human islet α-cells also appear to poised for reprogramming into insulin-positive cells. Here we have generated transgenic mice conditionally expressing ...[more]