Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development?
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ABSTRACT: Objective
We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth.Research design and methods
We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sex- and age-specific ceBMI thresholds for greatest type 1 diabetes risk.Results
Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects and in females versus males.Conclusions
Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age.
SUBMITTER: Ferrara CT
PROVIDER: S-EPMC5399656 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Publications
Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development?
Ferrara Christine Therese CT Geyer Susan Michelle SM Liu Yuk-Fun YF Evans-Molina Carmella C Libman Ingrid M IM Besser Rachel R Becker Dorothy J DJ Rodriguez Henry H Moran Antoinette A Gitelman Stephen E SE Redondo Maria J MJ
Diabetes care 20170215 5
<h4>Objective</h4>We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth.<h4>Research design and methods</h4>We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sex- and age-spe ...[more]
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