Ontology highlight
ABSTRACT:
SUBMITTER: Moskowitz DM
PROVIDER: S-EPMC5399889 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Moskowitz David M DM Zhang David W DW Hu Bin B Le Saux Sabine S Yanes Rolando E RE Ye Zhongde Z Buenrostro Jason D JD Weyand Cornelia M CM Greenleaf William J WJ Goronzy Jörg J JJ
Science immunology 20170217 8
The efficacy of the adaptive immune response declines dramatically with age, but the cell-intrinsic mechanisms driving immune aging in humans remain poorly understood. Immune aging is characterized by a loss of self-renewing naïve cells and the accumulation of differentiated but dysfunctional cells within the CD8 T cell compartment. Using ATAC-seq, we inferred the transcription factor binding activities correlated with naive and central and effector memory CD8 T cell states in young adults. Inte ...[more]