Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma.
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ABSTRACT:
SUBMITTER: Chandrawati R
PROVIDER: S-EPMC5400071 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma.
Chandrawati Rona R Chang Jason Y H JYH Reina-Torres Ester E Jumeaux Coline C Sherwood Joseph M JM Stamer W Daniel WD Zelikin Alexander N AN Overby Darryl R DR Stevens Molly M MM
Advanced materials (Deerfield Beach, Fla.) 20170221 16
Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location- and dose-dependent. A NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model. ...[more]
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