Sheet Probability Index (SPI): Characterizing the geometrical organization of the white matter with diffusion MRI.

ABSTRACT: The question whether our brain pathways adhere to a geometric grid structure has been a popular topic of debate in the diffusion imaging and neuroscience societies. Wedeen et al. (2012a, b) proposed that the brain's white matter is organized like parallel sheets of interwoven pathways. Catani et al. (2012) concluded that this grid pattern is most likely an artifact, resulting from methodological biases that cause the tractography pathways to cross in orthogonal angles. To date, ambiguities in the mathematical conditions for a sheet structure to exist (e.g. its relation to orthogonal angles) combined with the lack of extensive quantitative evidence have prevented wide acceptance of the hypothesis. In this work, we formalize the relevant terminology and recapitulate the condition for a sheet

SUBMITTER: Tax CMW 

PROVIDER: S-EPMC5400114 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature