Ontology highlight
ABSTRACT:
SUBMITTER: Gopal A
PROVIDER: S-EPMC5400225 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Gopal Ashidha A Chidambaram Iyer Soumya IS Devaraj Niranjali N Devaraj Halagowder H
PloS one 20170421 4
Shigella dysenteriae (S.dysenteriae) the causative agent of bacillary dysentery invades the human colonic epithelium resulting in severe intestinal inflammatory response and epithelial destruction. However, the mechanism by which S.dysenteriae infection regulates proinflammatory cytokines during intestinal inflammation is still obscure. In this study, we evaluated whether the interaction of β-catenin and NF-κB regulates proinflammatory cytokines TNF-α and IL-8 by modulating GSK-3β activity durin ...[more]