Quantification of hypoxia-related gene expression as a potential approach for clinical outcome prediction in breast cancer.

ABSTRACT: Breast cancers are solid tumors frequently characterized by regions with low oxygen concentrations. Cellular adaptations to hypoxia are mainly determined by "hypoxia inducible factors" that mediate transcriptional modifications involved in drug resistance and tumor progression leading to metastasis and relapse occurrence. In this study, we investigated the prognostic value of hypoxia-related gene expression in breast cancer. A systematic review was conducted to select a set of 45 genes involved in hypoxia signaling pathways and breast tumor progression. Gene expression was quantified by RT-qPCR in a retrospective series of 32 patients with invasive ductal carcinoma. Data were analyzed in relation to classical clinicopathological criteria and relapse occurrence. Coordinated overexpression o

SUBMITTER: El Guerrab A 

PROVIDER: S-EPMC5400273 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature