Ontology highlight
ABSTRACT: Objective
Breastfeeding has been linked to lower rates of childhood obesity. Human milk contains cortisol, known to regulate glucose storage and metabolism. The aim of this study was to to test the hypothesis that early exposure to cortisol in human breast milk helps to modulate infant body mass index (BMI) trajectories over the first 2 years of life.Methods
Growth curve modeling was used to examine whether infant exposure to cortisol in human milk at 3 months predicted changes in child body mass index percentile (BMIP) at 6, 12, and 24 months of age in 51 breastfeeding mother-child pairs.Results
Infants exposed to higher milk cortisol levels at 3 months were less likely to exhibit BMIP gains over the first 2 years of life, compared with infants exposed to lower milk cortisol. By age 2, infants exposed to higher milk cortisol levels had lower BMIPs than infants exposed to lower milk cortisol. Milk cortisol was a stronger predictor of BMIP change in girls than boys.Conclusions
Cortisol exposure through human milk may help to program metabolic functioning and childhood obesity risk. Further, because infant formula contains only trace amounts of glucocorticoids, these findings suggest that cortisol in milk is a novel biological pathway through which breastfeeding may protect against later obesity.
SUBMITTER: Hahn-Holbrook J
PROVIDER: S-EPMC5400496 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Hahn-Holbrook Jennifer J Le Tran Bao TB Chung Anna A Davis Elysia Poggi EP Glynn Laura M LM
Obesity (Silver Spring, Md.) 20161201 12
<h4>Objective</h4>Breastfeeding has been linked to lower rates of childhood obesity. Human milk contains cortisol, known to regulate glucose storage and metabolism. The aim of this study was to to test the hypothesis that early exposure to cortisol in human breast milk helps to modulate infant body mass index (BMI) trajectories over the first 2 years of life.<h4>Methods</h4>Growth curve modeling was used to examine whether infant exposure to cortisol in human milk at 3 months predicted changes i ...[more]