Ontology highlight
ABSTRACT:
SUBMITTER: Mesrouze Y
PROVIDER: S-EPMC5400505 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Mesrouze Yannick Y Bokhovchuk Fedir F Meyerhofer Marco M Fontana Patrizia P Zimmermann Catherine C Martin Typhaine T Delaunay Clara C Erdmann Dirk D Schmelzle Tobias T Chène Patrick P
eLife 20170421
TEAD (<i>TEA</i>/ATTS <i>d</i>omain) transcription factors are the most distal effectors of the Hippo pathway. YAP (<i>Y</i>es-<i>a</i>ssociated <i>p</i>rotein) is a coactivator protein which, upon binding to TEAD proteins, stimulates their transcriptional activity. Since the Hippo pathway is deregulated in various cancers, designing inhibitors of the YAP:TEAD interaction is an attractive therapeutic strategy for oncology. Understanding the molecular events that take place at the YAP:TEAD interf ...[more]